Název: Effect of nanodiamond particles on neuronal tissue
Autoři: Šimková, Veronika ; Benson, Veronika
Typ dokumentu: Příspěvky z konference
Konference/Akce: Instruments and Methods for Biology and Medicine 2018, Kladno (CZ), 20180510
Rok: 2018
Jazyk: eng
Abstrakt: High-Pressure High-Temperature nanodiamonds are considered to be highly biocompatible due to\ntheir low acute toxicity, which makes them suitable for biomedical applications. However, next to interaction with the cell membrane, nanoscale allows particles to penetrate the plasma membrane and even accumulate in the cell cytoplasm. Recently it brought up questions regarding sustainable nanoparticle application in vivo and potential toxicity hazards. The neuronal tissue consists of neurons and glial cells, and it is separated by a bloodbrain barrier from the peripheral blood system. Neurons are nerve cells forming a complex network of synapses that carry signals in the brain. The neurons are nourished and protected by glial cells. This project aims to find out whether nanodiamonds pass the blood-brain barrier when applied intravenously as a drug carrier and whether they directly interact with the neuronal tissue.
Klíčová slova: cell cytoplasm; nanodiamonds; neuronal tissue
Zdrojový dokument: IMBM 2018 Proceedings, ISBN 978-80-01-06502-0

Instituce: Mikrobiologický ústav AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0292238

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-391551


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Mikrobiologický ústav
Konferenční materiály > Příspěvky z konference