Biologická aktivita vybraných taxonů hub z oddělení Ascomycota a Basidiomycota

Macáková, Kateřina

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate Ing. Kateřina Macáková Supervisor Doc. RNDr. Lubomír Opletal, CSc. Title of Doctoral Thesis Biological activity of selected taxons of mushrooms from divisions Ascomycota and Basidiomycota. Though they are relatively insufficiently explored, mushroom are considered to be important source of bioactive substances, which is evident especially in Asian countries where some species of mushrooms, eventually their extracts or substances isolated from them, are used for healing of some diseases. This study, which covers 357 tested species of mushrooms growing in Czech Republic, focuses especially on antioxidant activity of mushroom extracts (2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and hydroxyl radical scavenging activity). Inhibitory activity towards human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) was also observed. For determination of antiradical activity, DPPH radical scavenging assay with the use of sequential injection analysis and chemiluminescence method for hydroxyl radical scavenging with the use of luminol were utilized. Total amount of phenolic substances was determined in the most active species. The correlation analysis showed that...

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