Název: Hodnocení a optimalizace granulačního procesu na laboratorním fluidním granulátoru.
Překlad názvu: Evaluation and optimisation of a granulation process on a laboratory scale fluid bed granulator.
Autoři: Stoniš, Jan ; Mužíková, Jitka (vedoucí práce) ; Řehula, Milan (oponent)
Typ dokumentu: Diplomové práce
Rok: 2013
Jazyk: eng
Abstrakt: The fluid bed granulation is a well-established method how to improve such properties of powders as flowability and increase content uniformity of the tablets. In this thesis, there was evaluated a granulation process on a lab scale fluid Glatt bed granulator and optimized for highest possible yield. Product yield in the size range of 80-90 % of granules and process reproducibility were stated as most effective. The product was analysed for its particle size distribution, the API distribution within the different particle size fractions and the flowability of the final granules. For process optimization, the most critical parameters such as spraying rate, particle size of raw materials and fluid bed pressure were identified and evaluated. As the highest-yielding dosage for the powder binder was found the spraying rate of 9 g/min. Changes in bed fluid pressure and nozzle pressure showed no significant improvement. Different grades of caffeine were compared for their impact on the granulation properties. Sieved caffeine enhanced yield of the product and reproducibility compared to bulk or disagglomerated caffeine.
Klíčová slova: fluid bed granulator; fluid bed pressure; granulation process; NIR measuring; particle size; spraing rate

Instituce: Fakulty UK (VŠKP) (web)
Informace o dostupnosti dokumentu: Dostupné v digitálním repozitáři UK.
Původní záznam: http://hdl.handle.net/20.500.11956/57976

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-327236


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Univerzita Karlova > Fakulty UK (VŠKP)
Vysokoškolské kvalifikační práce > Diplomové práce