Molekulární podstaty efektu cvičení na zdraví kosti po menopauze

Mocová, Klára

Hormonal changes caused by menopause, most notably the decline in estradiol levels, lead to rapid bone loss, putting a significant percentage of postmenopausal women at serious risk of developing osteoporosis. Postmenopausal osteoporosis influences many aspects of women's health and their overall well-being. Regular physical activity is considered one of the essential means to slow the bone loss process and prevent bone fragility. Many molecules play a role in the reaction of bone to mechanical stress during exercise, both those produced directly by bone cells and those expressed by other tissues, such as myokines and cytokines. The molecular connections between the menopausal changes in bone and the skeletal reaction to exercise are not well-known, especially considering variables like different types of exercise or individual levels of osteoporosis risk. Learning more about these links could help us better understand how exactly exercise influences postmenopausal bones. Moreover, it would be beneficial for creating more effective guidelines for osteoporosis prevention through exercise and developing better prevention and treatment approaches for postmenopausal osteoporosis. Keywords: menopause, bone metabolism, physical activity, exercise, postmenopausal osteoporosis

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